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2 More Stem Cell Research Papers Show Adult Stem Cells Help Heart Disease
As if we needed more evidence that adult stem cells help heart disease, today, we have two more research studies that add to our already huge list. First, we have a research study coming out of Brazil, where doctors injected 8 angina patients with stem cells from the patient's own bone marrow.
The research study in Brazil found that all 8 heart patients improved after having their own stem cells implanted into their myocardium. Here is the
full research study for the heart study:
The researchers found that the procedure benefitted all eight of the refractory angina patients in the study, all of whom had previously received surgical revascularization.
"The large fraction of monocytes in the ReACT formula appears to be related to the new blood vessel growth, or angiogenesis, that restores perfusion on the myocardial ischemic areas after the cell transplantation," said corresponding author Dr. Nelson Americo Hossne, Jr. of the Paulista School of Medicine, Federal University of Sao Paulo. "For our patients, angina symptom relief began as early as three months post-procedure with continuing improvement through the twelfth month and sustained improvement past 18 months. Symptom relief improved in all patients, suggesting that the effect is sustained, not transitory."
"This results in a substantial decrease in the quality of life for the refractory angina patient," added Prof. Enio Buffolo.
Bone marrow is a natural source of a broad spectrum of cytokines involved in controlling angiogenic and inflammatory processes. Bone marrow white blood cells therefore play an important role in the angiogenic mechanism, contributing to the revascularization of the heart.
Next, we have a study from China in which they showed that apelin, a newly described inotropic peptide, improves heart function following transplantation of stem cells from the patient's own bone marrow.
From the
stem cell news story:
Apelin helps heart function after bone marrow transplant
Apelin, a newly described inotropic peptide (related to the force of heart muscle contraction) with important cardiovascular regulatory properties, contributes to functional improvement in patients with severe heart failure after they have undergone implantation with bone marrow mononuclear cells (BMMC). The study, carried out at the Navy General Hospital in Beijing, evaluated 40 patients with severe heart failure following myocardial infarction. Twenty patients were assigned to receive BMMC transplants and 20 received standard medication. Another 20 healthy patients were assigned as controls.
"Baseline levels of plasma apelin were significantly lower in all heart failure patients as compared to normal, healthy subjects," said corresponding author Dr. Lian Ru Gao. "However, in patients who underwent cell transplantation, apelin increased significantly from three to 21 days post-transplantation. This increase in apelin was also followed by significant improvement in cardiac function."
In patients who received standard treatment, there was no increase in apelin.
Ok-- I think this research study is saying that the stem cells somehow increase apelin which is responsible for helping increase heart function.
More Proof Needed?
Please feel free to peruse our Heart Disease section for more proof that
adult stem cells are helping heart patients now. Unfortunately, not in the United States except for clinical trials which are difficult to qualify for and you may get the placebo-- nice going FDA.