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Another "works on mice" study using repair (adult) stem cell therapy and you all know I don't like to chronicle these stem cell research studies until they begin to work in humans, but this one sounds more promising than most and this study surprises me not in the least:
Medical researchers at University of North Carolina-Chapel Hill announced recently that they have made strides in the technology to rebuild damaged bone tissue using stem cells. The research team, led by Dr. Anna Spagnoli, an associate professor of pediatrics at the university, derived the stem cells from bone marrow samples to locate and repair broken bones in mice. Now the work is poised to move to humans.It's a field that is generating possibilities. A recent case in Germany, in which a man lost his jaw to an aggressive tumor, was reported in the journal Lancet in 2004. In that instance, German scientists used a titanium jaw prosthesis as a scaffold in which they planted stem cells extracted from the patient's bone marrow. The scaffold served as a mold for a new jawbone to grow from the cells. (This is one of my favorite repair stem cell stories ever!- DM)But how do the stem cells know where to go when they are injected into the body? Spagnoli's team noticed that a certain molecule in the stem cells was the key to homing in on the fracture. The molecule, called CXR4, was responding to a chemical signal sent out by the damaged bone."Nobody knew if the stem cells would even go to the place where they were needed -- the fracture," Spagnoli said "We put the mice in a dark box and we saw the light, and we could see it was going to the right place," Spagnoli said. "It's like the fracture is sending out a message that says 'please come here, there is help needed here,'" Spagnoli said. (And that is the precisely the reason why I call them repair stem cells! The body cries for help and the repair stem cells listen and respond-DM)Click here to read the whole thing